Translational Fund Projects

Understanding the senolytic and senomorphic effects of zoledronate treatment in an aging mouse model using spatial transcriptomics

Project lead:

Gayle Marshall, Medicines Discovery Catapult

Co-Investigators: James Edwards, University of Oxford; Eleanor Platt, Medicines Discovery Catapult

Epigenetic modulation in a human in vitro model to prevent ageing

Project lead:

Graeme Wilkinson, Medicines Discovery Catapult

Co-Investigators: Nicholas Rattray, University of Strathclyde; Lorna FitzPatrick, Medicines Discovery Catapult

Generation of monoclonal antibodies targeting novel thrombotic interaction between neutrophils and platelets

Project lead:

Julie Rayes, University of Birmingham

Improving vaccination in older adults by inducing autophagy with spermidine

Project lead:

Katja Simon, University of Oxford

Co-Investigators: Paul Klenerman, University of Oxford

The role and mechanisms of mTOR inhibition in ameliorating immune ageing features in humans

Project lead:

Lynne Cox, University of Oxford, and Philip Atherton, University of Nottingham

Validation of in-vivo senescent cell imaging using the fluorine labelled β-galactosidase substrate, PyGal

Project lead:

Satomi Miwa, Newcastle University

Co-Investigators: Ross Maxwell, Newcastle University; Stephen Hobson, Newscastle University